Mechanisms of Resistance to Quinolones and Epidemiological Significance of Salmonella spp.

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MECHANISMS OF RESISTANCE TO QUINOLONES AND EPIDEMIOLOGICAL SIGNIFICANCE OF Salmonella spp

Bacteria develop resistance to antimicrobial agents by a number of different mechanisms. The resistance to (fluoro)quinolones in Salmonella is of particular importance especially if therapy in humans is required. For decades there has been a significant interest in studying the biology of Salmonella because these bacteria are among the leading causes of foodborne illnesses around the globe. To ...

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Mechanisms of resistance to quinolones.

The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to fluoroquinolones typically arises as a result of alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux. Mutations are selected first in the more susceptible t...

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[Mechanisms of plasmid-mediated resistance to quinolones].

Quinolone resistance is caused mainly by chromosomal mutations in gram negative bacteria. In 1998, plasmid-mediated resistance to quinolones in clinical isolates was first reported in a Klebsiella pneumoniae strain. Locus qnr (quinolone resistance) was responsible of the quinolone resistance in this plasmid. qnr codes a protein whose function is protect both DNA-girase and topoisomerase IV from...

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ژورنال

عنوان ژورنال: Acta Veterinaria

سال: 2016

ISSN: 1820-7448

DOI: 10.1515/acve-2016-0013